Association of severity of coexisting patellofemoral disease with increased impairments and functional limitations in patients with knee osteoarthritis

Arthritis Care Res (Hoboken). 2013 Apr;65(4):544-51. doi: 10.1002/acr.21866.


Objective: To evaluate the association between severity of coexisting patellofemoral (PF) disease with lower extremity impairments and functional limitations in patients with tibiofemoral (TF) osteoarthritis (OA).

Methods: Radiographic views of the TF and PF compartments, knee extension strength, and knee range of motion were obtained for 167 patients with knee OA. Additionally, knee-specific symptoms and functional limitations were assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) and the Activities of Daily Living Scale (ADLS).

Results: Moderate/severe PFOA was associated with lower knee extension strength (mean ± SD 1.4 ± 0.5 Nm/body weight [BW]) compared to no PFOA (mean ± SD 1.8 ± 0.5 Nm/BW). Additionally, total knee range of motion was significantly lower for patients with moderate/severe PFOA (mean ± SD 120.8° ± 14.4°) compared to no PFOA (mean ± SD 133.5° ± 10.7°) and mild PFOA (mean ± SD 125.8° ± 13.0°). Moderate/severe PFOA and mild PFOA were also associated with less pain while standing (odds ratio [OR] 0.2, 95% confidence interval [95% CI] 0.1-0.7 and OR 0.2, 95% CI 0.1-0.6, respectively) on the WOMAC, and moderate/severe PFOA was associated with greater difficulty with going downstairs (OR 2.9, 95% CI 1.0-8.1) on the ADLS.

Conclusion: It appears that knees with more severe coexisting PF disease demonstrate features distinct from those observed in TFOA in isolation or in combination with mild PF disease. Treatment strategies targeting the PF joint may be warranted to mitigate the specific lower extremity impairments and functional problems present in this patient population.

Publication types

  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, N.I.H., Extramural

MeSH terms

  • Activities of Daily Living*
  • Aged
  • Female
  • Humans
  • Knee Joint / diagnostic imaging
  • Knee Joint / physiopathology*
  • Male
  • Middle Aged
  • Osteoarthritis / complications
  • Osteoarthritis / diagnostic imaging
  • Osteoarthritis / physiopathology
  • Osteoarthritis, Knee / complications*
  • Osteoarthritis, Knee / diagnostic imaging
  • Osteoarthritis, Knee / physiopathology
  • Patellofemoral Joint / diagnostic imaging
  • Patellofemoral Joint / physiopathology*
  • Radiography
  • Range of Motion, Articular*
  • Severity of Illness Index
  • Surveys and Questionnaires