Immunoglobulin-specific Responses to Chlamydia Elementary Bodies in Individuals With and at Risk for Genital Chlamydial Infection

J Infect Dis. 2012 Dec 15;206(12):1836-43. doi: 10.1093/infdis/jis621. Epub 2012 Oct 8.

Abstract

Renewed interest in chlamydia vaccination has revealed the need for a greater understanding of the seroprevalence of chlamydial infection in US populations. We used a Chlamydia trachomatis elementary body (EB)-based enzyme-linked immunosorbent assay to define the characteristics of the humoral immune response and to determine seroprevalence. Two groups were analyzed: one consisting of patients with current, laboratory confirmed, genital chlamydial infection (n = 98) and one group of individuals whose chlamydia infection history was unknown (n = 367). C. trachomatis seropositivity was detected in 90% of the infected group and in 31% of the chlamydia-unknown group. IgG1 and IgG3 comprised the predominant anti-Chlamydia serum antibody responses. Serum IgA1 responses were variably positive, and individuals were rarely positive for anti-chlamydia IgG2, IgG4 or IgA2. The magnitude of the IgG1 and IgG3 responses was greatest in female and African American individuals and was sustained for at least 6 months. Antibody responses were not serovar restricted or confounded by Chlamydia pneumoniae cross-reactivity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Antibodies, Bacterial / blood*
  • Antigens, Bacterial
  • Chlamydia Infections / epidemiology*
  • Chlamydia Infections / immunology
  • Chlamydia trachomatis / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Ethnic Groups
  • Female
  • Humans
  • Immunoglobulin A / blood
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Seroepidemiologic Studies
  • Sex Factors
  • United States / epidemiology
  • Young Adult

Substances

  • Antibodies, Bacterial
  • Antigens, Bacterial
  • Immunoglobulin A
  • Immunoglobulin G