Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach

Neurosci Lett. 1990 Jan 1;108(1-2):195-200. doi: 10.1016/0304-3940(90)90730-w.

Abstract

It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation. This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. High-pressure liquid chromatography revealed only one peak of immunoreactivity coeluting with synthetic CGRP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcitonin Gene-Related Peptide / metabolism*
  • Capsaicin / pharmacology*
  • Gastric Mucosa / metabolism*
  • In Vitro Techniques
  • Male
  • Perfusion
  • Rats
  • Rats, Inbred Strains
  • Stomach / drug effects

Substances

  • Calcitonin Gene-Related Peptide
  • Capsaicin