The neural correlates of emotion-based cognitive control in adults with early childhood behavioral inhibition

Biol Psychol. 2013 Feb;92(2):306-14. doi: 10.1016/j.biopsycho.2012.09.008. Epub 2012 Oct 6.

Abstract

The present study is the first to assess whether the neural correlates of cognitive control processes differ in adults with and without a behaviorally inhibited temperament during early childhood. Adults with and without childhood behavioral inhibition completed an emotional conflict task while undergoing functional magnetic resonance imaging scanning. While no group differences in behavior were observed, adults with childhood behavioral inhibition, relative to adults without childhood behavioral inhibition, exhibited greater dorsomedial prefrontal cortex activity during conflict detection and greater putamen activity during conflict adaptation. Lifetime psychopathology predicted behavioral, but not brain-related, differences in conflict adaptation. These data suggest that the brain regions underlying cognitive control processes are differentially influenced by childhood behavioral inhibition, and may be differently related to psychopathology.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural

MeSH terms

  • Adaptation, Physiological
  • Adolescent
  • Brain / blood supply
  • Brain / physiology*
  • Brain Mapping*
  • Cognition / physiology*
  • Emotions / physiology*
  • Female
  • Humans
  • Image Processing, Computer-Assisted
  • Inhibition, Psychological*
  • Longitudinal Studies
  • Magnetic Resonance Imaging
  • Male
  • Oxygen / blood
  • Psychiatric Status Rating Scales
  • Young Adult

Substances

  • Oxygen