The effect of a single dose of acetaminophen on airways response in children with asthma

Clin Pediatr (Phila). 2013 Jan;52(1):42-8. doi: 10.1177/0009922812462764. Epub 2012 Oct 9.


Accumulating evidence suggests that the use of acetaminophen increases the risk of developing asthma and that its widespread use has contributed to the increasing prevalence of asthma.

Study design: To investigate the immediate effect of a single dose of acetaminophen on airways reactivity and inflammation in asthmatic and controls. A double blind placebo-controlled study was conducted on 42 asthmatic children and 21 healthy age-matched controls. Each participant received one oral dose of acetaminophen (15 mg/kg [160 mg/mL]) and one dose of a volume-matched placebo. Physical examination, spirometry results, and fractional exhaled nitric oxide levels were assessed before and 60 minutes following acetaminophen or placebo ingestion.

Results: None of the studied variables showed any significant change after acetaminophen or placebo ingestion in either the asthmatic or the control groups.

Conclusions: One single dose of acetaminophen neither evokes a bronchoconstriction response nor an increase in airway inflammation in children with asthma.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acetaminophen / administration & dosage*
  • Adolescent
  • Analgesics, Non-Narcotic / administration & dosage*
  • Asthma / drug therapy*
  • Bronchi / drug effects*
  • Bronchial Hyperreactivity / drug therapy
  • Bronchoconstriction / physiology
  • Child
  • Cross-Over Studies
  • Double-Blind Method
  • Female
  • Humans
  • Male
  • Nitric Oxide / administration & dosage
  • Pilot Projects
  • Spirometry


  • Analgesics, Non-Narcotic
  • Nitric Oxide
  • Acetaminophen