Association between the IVS4G>T mutation in the TCF7L2 gene and susceptibility to diabetes in cystic fibrosis patients

BMC Res Notes. 2012 Oct 10;5:561. doi: 10.1186/1756-0500-5-561.

Abstract

Background: Clinical complications appear to be a decisive factor for the prognosis of patients. Diabetes is an important complication of cystic fibrosis(CF). In our study we evaluated the association between the IVS4G>T mutation in the TCF7L2 gene with the presence of diabetes in patients with CF.

Findings: We evaluated 145 patients with CF in relation to the genotype of the IVS4G>T mutation. For this, the PCR method associated with specific enzyme digestion was used. The genotypes G/G, G/T and T/T were observed to have frequencies of 54 (37.2%), 78 (53.8%) and 13 (9%), respectively. There was no association between genotype and the occurrence of diabetes among patients.

Conclusions: In our sample, no association was found between the IVS4G>T mutation in the TCF7L2 gene and diabetes.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brazil / epidemiology
  • Child
  • Comorbidity
  • Cystic Fibrosis / epidemiology
  • Cystic Fibrosis / genetics*
  • Cystic Fibrosis Transmembrane Conductance Regulator / genetics*
  • Diabetes Mellitus / epidemiology
  • Diabetes Mellitus / genetics*
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Male
  • Mutation*
  • Polymorphism, Single Nucleotide
  • Transcription Factor 7-Like 2 Protein / genetics*

Substances

  • TCF7L2 protein, human
  • Transcription Factor 7-Like 2 Protein
  • Cystic Fibrosis Transmembrane Conductance Regulator