Cancer biology: a new RING to Wnt signaling

Curr Biol. 2012 Oct 9;22(19):R849-51. doi: 10.1016/j.cub.2012.08.002.

Abstract

The β-catenin-dependent Wnt signaling pathway has key roles in embryonic development and adult tissues and is defective in various cancers. Recent studies highlight the function of two transmembrane RING finger ubiquitin ligases in modulating Wnt signaling and reveal roles for mutations in the RING finger proteins in cancer.

Publication types

  • Comment

MeSH terms

  • Animals
  • DNA-Binding Proteins / metabolism*
  • Endocytosis*
  • Female
  • Humans
  • Male
  • Oncogene Proteins / metabolism*
  • Receptors, Wnt / metabolism*
  • Stem Cells / enzymology*
  • Thrombospondins / metabolism*
  • Tumor Suppressor Proteins / metabolism*
  • Ubiquitin-Protein Ligases / deficiency*
  • Ubiquitin-Protein Ligases / metabolism*
  • Wnt Signaling Pathway*

Substances

  • DNA-Binding Proteins
  • Oncogene Proteins
  • Receptors, Wnt
  • Thrombospondins
  • Tumor Suppressor Proteins
  • Ubiquitin-Protein Ligases