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. 2012 Oct 24;134(42):17456-8.
doi: 10.1021/ja3084797. Epub 2012 Oct 12.

Nickel-mediated Oxidative Fluorination for PET With Aqueous [18F] Fluoride

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Free PMC article

Nickel-mediated Oxidative Fluorination for PET With Aqueous [18F] Fluoride

Eunsung Lee et al. J Am Chem Soc. .
Free PMC article

Abstract

A one-step oxidative fluorination for carbon-fluorine bond formation from well-defined nickel complexes with oxidant and aqueous fluoride is presented, which enables a straightforward and practical (18)F late-stage fluorination of complex small molecules with potential for PET imaging.

Figures

Scheme 1
Scheme 1
Two-Step Late-Stage Fluorination via Pd(IV) Fluoride Complex 4.
Scheme 2
Scheme 2
Synthesis of Ni(II) Aryl Complexes

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