Anti-tumour immunotherapy with Vγ9Vδ2 T lymphocytes: from the bench to the bedside

Br J Haematol. 2013 Jan;160(2):123-32. doi: 10.1111/bjh.12090. Epub 2012 Oct 15.

Abstract

Gamma delta (γδ) Τ cells are non-conventional T lymphocyte effectors that can interact with and eradicate tumour cells. Several data demonstrate that these T cells, which are implicated in the first line of defence against pathogens, have anti-tumour activity against many cancers and suggest that γδ Τ cell-mediated immunotherapy is feasible and might induce objective tumour responses. Due to the importance of γδ Τ lymphocytes in the induction and control of immunity, a complete understanding of their biology is crucial for the development of a potent cancer immunotherapy. This review discusses recent advances in γδ Τ basic research and data from clinical trials on the use of γδ Τ cells in the treatment of different cancers. It analyses how this knowledge might be applied to develop new strategies for the clinical manipulation and the potentiation of γδ Τ lymphocyte activity in cancer immunotherapy.

Publication types

  • Review

MeSH terms

  • Adaptive Immunity
  • Adjuvants, Immunologic / pharmacology
  • Antigens, Neoplasm / immunology
  • CD8-Positive T-Lymphocytes / immunology
  • Cells, Cultured / drug effects
  • Cells, Cultured / immunology
  • Cells, Cultured / transplantation
  • Clinical Trials as Topic
  • Dendritic Cells / immunology
  • Dendritic Cells / transplantation
  • Diphosphonates / pharmacology
  • Diphosphonates / therapeutic use
  • Gene Rearrangement, delta-Chain T-Cell Antigen Receptor
  • Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
  • Humans
  • Immunity, Innate
  • Immunologic Surveillance / immunology
  • Immunotherapy, Adoptive*
  • Killer Cells, Natural / immunology
  • Mesenchymal Stem Cells / immunology
  • Neoplasms / immunology
  • Neoplasms / therapy*
  • Receptors, Antigen, T-Cell, alpha-beta / analysis
  • Receptors, Antigen, T-Cell, gamma-delta / analysis*
  • Receptors, Antigen, T-Cell, gamma-delta / genetics
  • T-Lymphocyte Subsets / chemistry
  • T-Lymphocyte Subsets / immunology
  • T-Lymphocyte Subsets / transplantation*
  • T-Lymphocytes, Cytotoxic / chemistry
  • T-Lymphocytes, Cytotoxic / immunology
  • T-Lymphocytes, Cytotoxic / transplantation*
  • T-Lymphocytes, Regulatory / immunology
  • Translational Medical Research
  • Tumor Escape / immunology

Substances

  • Adjuvants, Immunologic
  • Antigens, Neoplasm
  • Diphosphonates
  • Receptors, Antigen, T-Cell, alpha-beta
  • Receptors, Antigen, T-Cell, gamma-delta