Nucleosome positioning: multiple mechanisms toward a unifying goal

Mol Cell. 2012 Oct 12;48(1):1-2. doi: 10.1016/j.molcel.2012.09.015.


In this issue, Hughes et al. (2012) show that nucleosome positioning is determined not by any single mechanism, but by the coordinated action of multiple factors, including the underlying DNA sequence, species-specific DNA binding proteins, chromatin remodelers, and the transcription machinery.

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