A helicase with an extra spring in its step

Michael Schlierf; Taekjip Ha

doi:10.1016/j.cell.2012.09.031

A helicase with an extra spring in its step

Cell. 2012 Oct 12;151(2):244-6. doi: 10.1016/j.cell.2012.09.031.

Authors

Michael Schlierf¹, Taekjip Ha

Affiliation

¹ B CUBE, Center for Molecular Bioengineering, Technische Universität Dresden, 01062 Dresden, Germany. schlierf@bcube-dresden.de

PMID: 23063116
DOI: 10.1016/j.cell.2012.09.031

Abstract

DNA replication requires hexameric ring-shaped helicases that unwind double-stranded DNA. In this issue, Itsathitphaisarn et al. report a high-resolution crystal structure of DnaB in complex with single-stranded DNA and nucleotide triphosphate analogs, revealing a unique mechanism by which DnaB unwinds DNA two base pairs at a time.

Publication types

Comment
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Abstract

Publication types

Grants and funding