Abstract
Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.
Copyright © 2012 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Brain / metabolism*
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Brain / pathology
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Brain Diseases / genetics
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Brain Diseases / metabolism*
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Brain Diseases / pathology
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Brain-Derived Neurotrophic Factor / genetics
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Brain-Derived Neurotrophic Factor / metabolism
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Calcium / metabolism
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Gene Expression Regulation
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Humans
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Nerve Growth Factors / genetics
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Nerve Growth Factors / metabolism*
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Neurons / metabolism*
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Neurons / pathology
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Phospholipase C gamma / genetics
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Phospholipase C gamma / metabolism
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Phosphorylation
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Receptor, trkB / genetics
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Receptor, trkB / metabolism
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Receptors, GABA / genetics
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Receptors, GABA / metabolism
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Signal Transduction
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Synaptic Transmission / genetics
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gamma-Aminobutyric Acid / metabolism
Substances
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Brain-Derived Neurotrophic Factor
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Nerve Growth Factors
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Receptors, GABA
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gamma-Aminobutyric Acid
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BDNF protein, human
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Receptor, trkB
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Phospholipase C gamma
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Calcium