Phospholipase C-γ1 involved in brain disorders

Adv Biol Regul. 2013 Jan;53(1):51-62. doi: 10.1016/j.jbior.2012.09.008. Epub 2012 Sep 18.

Abstract

Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Brain / metabolism*
  • Brain / pathology
  • Brain Diseases / genetics
  • Brain Diseases / metabolism*
  • Brain Diseases / pathology
  • Brain-Derived Neurotrophic Factor / genetics
  • Brain-Derived Neurotrophic Factor / metabolism
  • Calcium / metabolism
  • Gene Expression Regulation
  • Humans
  • Nerve Growth Factors / genetics
  • Nerve Growth Factors / metabolism*
  • Neurons / metabolism*
  • Neurons / pathology
  • Phospholipase C gamma / genetics
  • Phospholipase C gamma / metabolism
  • Phosphorylation
  • Receptor, trkB / genetics
  • Receptor, trkB / metabolism
  • Receptors, GABA / genetics
  • Receptors, GABA / metabolism
  • Signal Transduction
  • Synaptic Transmission / genetics
  • gamma-Aminobutyric Acid / metabolism

Substances

  • Brain-Derived Neurotrophic Factor
  • Nerve Growth Factors
  • Receptors, GABA
  • gamma-Aminobutyric Acid
  • BDNF protein, human
  • Receptor, trkB
  • Phospholipase C gamma
  • Calcium