Successful treatment by adding duloxetine to pregabalin for peripheral neuropathy induced by paclitaxel

Am J Hosp Palliat Care. 2013 Nov;30(7):734-6. doi: 10.1177/1049909112463416. Epub 2012 Oct 11.


Although paclitaxel is a commonly used anticancer drug, peripheral neuropathy may develop as a side effect. Worsening of the symptoms with time may cause patients who receive paclitaxel to give up their chemotherapy. Duloxetine, a serotonin- and norepinephrine-reuptake inhibitor, has been used to treat peripheral neuropathic pain. We report the case of a 68-year-old man with gastric cancer, who underwent gastrectomy and then received 8 cycles of chemotherapy involving weekly administrations of paclitaxel. Under this paclitaxel treatment, he complained of severe peripheral neuropathy, leading to a diminished quality of life. Following treatment with a combination of duloxetine and pregabalin, a remission of his symptoms was achieved. Duloxetine plus pregabalin therapy may be useful for the peripheral neuropathy induced by paclitaxel.

Keywords: cancer; chemotherapy; duloxetine; paclitaxel; peripheral neuropathy; pregabalin.

MeSH terms

  • Duloxetine Hydrochloride*
  • Humans
  • Paclitaxel*
  • Peripheral Nervous System Diseases / chemically induced
  • Pregabalin
  • Quality of Life
  • Thiophenes


  • Thiophenes
  • Pregabalin
  • Duloxetine Hydrochloride
  • Paclitaxel