[Growing teratoma syndrome of the lung secondary to non-seminomatous germ cell tumor of the testis-a case report]

Gan To Kagaku Ryoho. 2012 Oct;39(10):1579-81.
[Article in Japanese]


We report a rare case of growing teratoma syndrome(GTS). The patient was a 37-year-old man diagnosed as having a mixed germ cell tumor of the right testis. After resection of the right testis, the patient developed multiple lung metastases and chemotherapy was administered. However, in spite of the normalization of the serum AFP level, the lung metastases continued to increase in size. The lung metastases were successfully resected and pathological examination revealed the diagnosis of a mature teratoma. GTS is defined as an enlarging tumor mass during or after chemotherapy in the case of germ cell tumors, with normalization of the serum AFP. Total surgical resection of the mass yielded a good result. Recognition of this syndrome is important for successful treatment.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Adult
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Humans
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / secondary*
  • Male
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / pathology*
  • Neoplasms, Germ Cell and Embryonal / surgery
  • Teratoma / drug therapy
  • Teratoma / pathology*
  • Teratoma / surgery
  • Tomography, X-Ray Computed