An assessment of the effects of impaired renal function and haemodialysis on the pharmacokinetics of fluconazole

Br J Clin Pharmacol. 1990 Feb;29(2):221-6. doi: 10.1111/j.1365-2125.1990.tb03623.x.


1. The oral pharmacokinetics of fluconazole were studied in three groups of volunteers (n = 5) with various degrees of renal function (GFR greater than 70 ml min-1; 20-70 ml min-1; less than 20 ml min-1) and in a group of patients with chronic end-stage renal failure requiring regular haemodialysis. 2. The pharmacokinetics of fluconazole were markedly affected by impaired renal function with the elimination of half-life in Group III (GFR less than 20 ml min-1) being approximately three times that observed in normal volunteers (Group I). 3. Fluconazole renal clearance was positively correlated with GFR. 4. Non-renal clearance of fluconazole decreased with decreasing renal function. 5. Approximately 38% of the 50 mg dose of fluconazole was removed by haemodialysis extending over a 3 h period.

MeSH terms

  • Adult
  • Aged
  • Chromatography, Gas
  • Female
  • Fluconazole / pharmacokinetics*
  • Glomerular Filtration Rate
  • Half-Life
  • Humans
  • Kidney Failure, Chronic / metabolism*
  • Kidney Failure, Chronic / physiopathology
  • Kidney Failure, Chronic / therapy
  • Male
  • Middle Aged
  • Renal Dialysis*


  • Fluconazole