Emergence of increased azithromycin resistance during unsuccessful treatment of Neisseria gonorrhoeae infection with azithromycin (Portland, OR, 2011)

Sex Transm Dis. 2012 Nov;39(11):877-9. doi: 10.1097/OLQ.0b013e3182685d2b.


We describe the emergence of an azithromycin-resistant Neisseria gonorrhoeae variant in a man from Portland, Oregon, during sole treatment with 2 g azithromycin. This report highlights the ease with which gonococcal macrolide resistance can emerge, the threat of multidrug resistant N. gonorrhoeae, and the need for adherence to Centers for Disease Control and Prevention treatment guidelines.

Publication types

  • Case Reports
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Anti-Bacterial Agents / pharmacology*
  • Azithromycin / pharmacology*
  • Centers for Disease Control and Prevention, U.S.
  • Drug Resistance, Bacterial / drug effects
  • Genotype
  • Gonorrhea / drug therapy*
  • Gonorrhea / epidemiology
  • Guideline Adherence
  • Humans
  • Male
  • Microbial Sensitivity Tests
  • Neisseria gonorrhoeae / drug effects*
  • Neisseria gonorrhoeae / isolation & purification*
  • Oregon
  • United States


  • Anti-Bacterial Agents
  • Azithromycin