Safety assessment of 1,2-glycols as used in cosmetics

Int J Toxicol. 2012 Sep-Oct;31(5 Suppl):147S-68S. doi: 10.1177/1091581812460409.

Abstract

Caprylyl glycol and related 1,2-glycols are used mostly as skin and hair conditioning agents and viscosity agents in cosmetic products, and caprylyl glycol and pentylene glycol also function as cosmetic preservatives. The Cosmetic Ingredient Review (CIR) Expert Panel noted that, while these ingredients are dermally absorbed, modeling data predicted decreased skin penetration of longer chain 1,2-glycols. Because the negative oral toxicity data on shorter chain 1,2-glycols and genotoxicity data support the safety of the 1,2-glycols reviewed in this safety assessment, the Panel concluded that these ingredients are safe in the present practices of use and concentration described in this safety assessment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Administration, Cutaneous
  • Animals
  • Consumer Product Safety*
  • Cosmetics / chemistry*
  • Cosmetics / toxicity
  • Dermatologic Agents / administration & dosage
  • Dermatologic Agents / chemistry
  • Dermatologic Agents / pharmacokinetics
  • Dermatologic Agents / toxicity*
  • Glycols / administration & dosage
  • Glycols / chemistry
  • Glycols / pharmacokinetics
  • Glycols / toxicity*
  • Humans
  • Lethal Dose 50
  • No-Observed-Adverse-Effect Level
  • Octanols / administration & dosage
  • Octanols / chemistry
  • Octanols / pharmacokinetics
  • Octanols / toxicity
  • Pentanes / administration & dosage
  • Pentanes / chemistry
  • Pentanes / pharmacokinetics
  • Pentanes / toxicity
  • Skin Care / adverse effects
  • Toxicity Tests
  • Viscosity

Substances

  • Cosmetics
  • Dermatologic Agents
  • Glycols
  • Octanols
  • Pentanes
  • 1,2-octanediol
  • 1,2-pentanediol