Obstructive sleep apnea: impact of hypoxemia on memory

Sleep Breath. 2013 May;17(2):811-7. doi: 10.1007/s11325-012-0769-0. Epub 2012 Oct 13.


Purpose: Attempts to understand the causes of cognitive impairment in obstructive sleep apnea (OSA) are complicated by the overlap among clinical and demographic factors that may impact cognition. The goal of the current study was to isolate the contribution of hypoxemia to cognitive impairment in OSA.

Methods: Two groups of 20 patients with newly diagnosed OSA were compared. The groups differed on severity of hypoxemia but not other demographic (e.g., age, gender, education, estimated premorbid IQ) or clinical (e.g., sleep related respiratory disturbances, daytime sleepiness, depressive symptoms) variables. Participants completed polysonmography and cognitive assessment.

Results: We compared patients with high and low hypoxemia on measures of memory, attention, executive functioning, and motor coordination using independent sample t-tests. The high hypoxemia group performed significantly better on immediate recall (Hopkins Verbal Learning Test - Revised; t = -2.50, p < 0.02) than the low hypoxemia group. No group differences were observed on other neuropsychological measures.

Conclusions: This study is one of the first to compare the cognitive performance of patients with high and low hypoxemia after controlling for demographic factors and aspects of OSA severity that could confound the relationship. In our carefully matched sample, we observed an unexpected advantage of higher hypoxemia on memory. These preliminary findings are discussed in the context of basic science literature on the protective effects of adaptation to intermittent hypoxemia. Our data suggest that the association between hypoxemia and cognition may not straightforward. Future research targeting the effects of hypoxemia on cognition controlling for other clinical factors in large groups of patients with OSA will be important.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Attention / physiology
  • Executive Function / physiology
  • Female
  • Humans
  • Hypoxia / diagnosis*
  • Hypoxia / physiopathology
  • Hypoxia / psychology*
  • Male
  • Memory Disorders / diagnosis*
  • Memory Disorders / physiopathology
  • Memory Disorders / psychology*
  • Mental Recall / physiology
  • Middle Aged
  • Neuropsychological Tests / statistics & numerical data
  • Polysomnography
  • Psychometrics / statistics & numerical data
  • Psychomotor Performance / physiology
  • Reference Values
  • Risk Factors
  • Sleep Apnea, Obstructive / diagnosis*
  • Sleep Apnea, Obstructive / physiopathology
  • Sleep Apnea, Obstructive / psychology*