A combined deficiency of factor VIII and contact activation defect in a family of cats

J D Littlewood; R J Evans

doi:10.1016/0007-1935(90)90073-C

A combined deficiency of factor VIII and contact activation defect in a family of cats

Br Vet J. 1990 Jan-Feb;146(1):30-5. doi: 10.1016/0007-1935(90)90073-C.

Authors

J D Littlewood¹, R J Evans

Affiliation

¹ Animal Health Trust, Newmarket, Suffolk.

PMID: 2306600
DOI: 10.1016/0007-1935(90)90073-C

Abstract

The coagulation parameters of a litter of kittens born to an obligate carrier of haemophilia A (classical haemophilia, factor VIII deficiency) are described. Three of four kittens were found to have an intrinsic coagulation defect, but only one was haemophilic. Factor XII deficiency was confirmed in one female, the other female and the dam being carriers of the defect. A confirmed haemophilic male from a previous litter was also found to be a factor XII deficient carrier.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Blood Coagulation Tests / veterinary
Cat Diseases / genetics*
Cats
Factor XII Deficiency / genetics
Factor XII Deficiency / veterinary
Female
Hemophilia A / genetics
Hemophilia A / veterinary*
Heterozygote
Male
Partial Thromboplastin Time / veterinary