Cerebellar vermis: essential for classically conditioned bradycardia in the rat

Brain Res. 1990 Feb 12;509(1):17-23. doi: 10.1016/0006-8993(90)90303-s.


The effects of lesions of the cerebellar vermis on the acquisition of heart-rate conditioning in rats was examined. Lesions of the vermis severely attenuated the acquisition of conditioned bradycardic responses in a simple conditioning procedure in restrained rats. Importantly, the vermal lesions did not affect resting heart-rate, unconditioned heart-rate orienting responses to a tone stimulus or unconditioned heart-rate responses to the shock unconditioned stimulus. It is concluded that the cerebellar vermis is an essential component of a heart-rate conditioned response circuit in the rat. The similarities between these effects and those following manipulations of the amygdala are discussed.

MeSH terms

  • Animals
  • Bradycardia / physiopathology*
  • Cardiovascular Physiological Phenomena*
  • Cerebellum / physiology*
  • Conditioning, Classical / physiology*
  • Male
  • Rats