Surface design of core-shell superparamagnetic iron oxide nanoparticles drives record relaxivity values in functional MRI contrast agents

Chem Commun (Camb). 2012 Dec 4;48(93):11398-400. doi: 10.1039/c2cc35515a. Epub 2012 Oct 12.


Core-shell hydrophilic superparamagnetic iron oxide (SPIO) nanoparticles, surface functionalized with either terephthalic acid or 2-amino terephthalic acid, showed large negative MRI contrast ability, validating the advantage of using low molecular weight and π-conjugated canopies for engineering functional nanostructures with superior performances.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Contrast Media / chemistry*
  • Contrast Media / toxicity
  • Drug Design*
  • Ferric Compounds / chemistry*
  • Ferric Compounds / toxicity
  • Magnetic Resonance Imaging / methods*
  • Magnets / chemistry*
  • Magnets / toxicity
  • Mice
  • NIH 3T3 Cells
  • Surface Properties


  • Contrast Media
  • Ferric Compounds
  • ferric oxide