Lamellar corneal transplantation

Surv Ophthalmol. 2012 Nov;57(6):510-29. doi: 10.1016/j.survophthal.2012.01.009.


Penetrating keratoplasty (PK) has been the gold standard for the surgical treatment of most corneal pathologies; lamellar keratoplasty that only replaces the diseased corneal layers has recently evolved as an alternative, however. Innovations in surgical technique and instrumentation provide visual outcomes comparable to PK. We review the indications and outcomes of various techniques of anterior lamellar surgery developed to treat stromal disorders. Similarly, we discuss posterior lamellar keratoplasty techniques such as Descemet stripping automated endothelial keratoplasty and Descemet membrane endothelial keratoplasty. Posterior lamellar keratoplasty provides faster visual rehabilitation than PK in cases of Fuchs endothelial dystrophy and pseudophakic bullous keratopathy. In addition, for medically unresponsive infectious keratitis, therapeutic anterior lamellar keratoplasty yields similar graft survival to PK without an increased risk of disease recurrence.

Publication types

  • Review

MeSH terms

  • Corneal Diseases / surgery*
  • Descemet Stripping Endothelial Keratoplasty / methods*
  • Epikeratophakia / methods*
  • Humans
  • Keratoplasty, Penetrating / methods