Diagnostic fiberoptic bronchoscopy and protected brush culture in patients with community-acquired pneumonia

Chest. 1990 Mar;97(3):576-82. doi: 10.1378/chest.97.3.576.


A model for performing fiberoptic bronchoscopy as a supplement to noninvasive diagnostic methods, in patients with community-acquired pneumonia, was prospectively studied. Twenty-four patients underwent bronchoscopy, seven pilot patients and 17 of 277 (6 percent) consecutive patients with CAP. Indications for FOB were early therapy failure (less than or equal to 72h)(n = 7), late therapy failure (greater than 72h)(n = 11), or before start of antibiotic therapy in severely ill or immunocompromised patients (n = 6). Samples were obtained by aspiration of bronchial secretion and with a protected brush catheter from which quantitative cultures with a detection level of 10(4) colony forming units per ml were performed. Results concluded that FOB, with the use of quantitative PB-cultures, offered a safe and specific diagnostic tool, which on special indications, can be of great value in the management of patients with CAP.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / therapeutic use
  • Bacterial Infections
  • Bronchoalveolar Lavage Fluid / microbiology
  • Bronchoscopes
  • Bronchoscopy / methods*
  • Catheterization, Peripheral / instrumentation*
  • Female
  • Fiber Optic Technology
  • Humans
  • Male
  • Middle Aged
  • Pilot Projects
  • Pneumonia / diagnosis*
  • Pneumonia / microbiology
  • Prospective Studies
  • Sputum / microbiology


  • Anti-Bacterial Agents