Isoflurane therapy for status asthmaticus in children and adults

Chest. 1990 Mar;97(3):698-701. doi: 10.1378/chest.97.3.698.


Two adults and two children with life-threatening asthma refractory to maximal standard therapy were treated with the inhalational anesthetic agent isoflurane. In each case, the temporal response to the initiation of therapy was striking. All patients survived and none experienced adverse reactions attributable to the drug. Rapid therapeutic benefit, minimal side effects, absence of cumulative toxicity, and ease of administration are factors supporting the use of isoflurane for patients with severe asthma.

Publication types

  • Case Reports

MeSH terms

  • Adolescent
  • Adult
  • Asthma / drug therapy*
  • Blood Gas Analysis
  • Bronchial Spasm / drug therapy
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Inspiratory Capacity / drug effects
  • Isoflurane / therapeutic use*
  • Lung Compliance / drug effects
  • Male
  • Status Asthmaticus / drug therapy*


  • Isoflurane