NMD: A Multifaceted Response to Premature Translational Termination

Nat Rev Mol Cell Biol. 2012 Nov;13(11):700-12. doi: 10.1038/nrm3454. Epub 2012 Oct 17.

Abstract

Although most mRNA molecules derived from protein-coding genes are destined to be translated into functional polypeptides, some are eliminated by cellular quality control pathways that collectively perform the task of mRNA surveillance. In the nonsense-mediated decay (NMD) pathway premature translation termination promotes the recruitment of a set of factors that destabilize a targeted mRNA. The same factors also seem to have key roles in repressing the translation of the mRNA, dissociating its terminating ribosome and messenger ribonucleoproteins (mRNPs), promoting the degradation of its truncated polypeptide product and possibly even feeding back to the site of transcription to interfere with splicing of the primary transcript.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Codon, Nonsense
  • Humans
  • Nonsense Mediated mRNA Decay*
  • Peptide Chain Termination, Translational / genetics*
  • Peptide Termination Factors / genetics
  • Peptide Termination Factors / metabolism*
  • Protein Biosynthesis
  • RNA Helicases
  • RNA Stability / genetics*
  • RNA, Messenger / genetics
  • RNA, Messenger / metabolism
  • RNA-Binding Proteins / metabolism
  • Ribonucleoproteins / genetics
  • Ribonucleoproteins / metabolism
  • Ribosomes / genetics
  • Ribosomes / metabolism
  • Trans-Activators / metabolism
  • Transcription Factors / metabolism

Substances

  • Codon, Nonsense
  • Peptide Termination Factors
  • RNA, Messenger
  • RNA-Binding Proteins
  • Ribonucleoproteins
  • Trans-Activators
  • Transcription Factors
  • UPF2 protein, human
  • UPF3A protein, human
  • RNA Helicases
  • UPF1 protein, human