ITP in Children: Pathophysiology and Current Treatment Approaches

J Pediatr Hematol Oncol. 2013 Jan;35(1):1-13. doi: 10.1097/MPH.0b013e318271f457.


Primary immune thrombocytopenia (ITP) is one of the most common bleeding disorders of childhood. In most cases, it presents with sudden widespread bruising and petechiae in an otherwise well child. Thought to be mainly a disorder of antibody-mediated platelet destruction, ITP can be self-limited or develop into a chronic condition. In this review, we discuss current concepts of the pathophysiology and treatment approaches to pediatric ITP.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Humans
  • Purpura, Thrombocytopenic, Idiopathic / physiopathology*
  • Purpura, Thrombocytopenic, Idiopathic / therapy*