Dual catalysis mode for the dicarbonyl reduction catalyzed by diketoreductase

Chem Commun (Camb). 2012 Nov 28;48(92):11352-4. doi: 10.1039/c2cc36334h.


Diketoreductase catalyzes a two-step bioreduction on a dicarbonyl substrate through a novel dual catalysis mode, in which random hydride attack simultaneously forms two mono-carbonyl intermediates, and subsequently distinct catalytic sites are responsible for the reductions of respective carbonyl group of the intermediates to yield the final dihydroxy product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Oxidoreductases / chemistry
  • Alcohol Oxidoreductases / metabolism*
  • Biocatalysis
  • Catalytic Domain
  • Hydrogen Bonding
  • Ketones / chemistry
  • Ketones / metabolism*
  • Oxidation-Reduction
  • Substrate Specificity


  • Ketones
  • Alcohol Oxidoreductases