Optical coherence tomography and ultrasound biomicroscopy imaging of opaque corneas

Cornea. 2013 Apr;32(4):e25-30. doi: 10.1097/ICO.0b013e318261eb2b.


Purpose: The purpose was to determine the interchangeability of ultrasound biomicroscopy (UBM) and anterior segment optical coherence tomography (AS-OCT) for corneal opacity depth measurement.

Methods: Twenty-six eyes of 26 consecutive patients with corneal opacities were examined by both AS-OCT and UBM. The corneal thickness and the corneal opacity depth were measured and compared. The interchangeability was determined by Bland-Altman plotting.

Results: The difference in the full corneal thickness and in the corneal opacity depth between OCT and UBM was 5 ± 7 μm and -1 ± 8 μm, respectively. There were strong correlations and no significant differences between the paired parameters (all r > 0.99, P < 0.01). The limits of agreement were 5 ± 14 μm for the corneal thickness and -1 ± 14.8 μm for the corneal opacity depth.

Conclusions: AS-OCT and UBM may be used interchangeably for measuring both full corneal thickness and corneal opacity depth in patients with corneal opacity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Corneal Opacity / diagnosis*
  • Corneal Stroma / pathology
  • Female
  • Humans
  • Male
  • Microscopy, Acoustic*
  • Middle Aged
  • Prospective Studies
  • Reproducibility of Results
  • Tomography, Optical Coherence*
  • Young Adult