The dual roles of homeobox genes in vascularization and wound healing

Cell Adh Migr. Nov-Dec 2012;6(6):457-70. doi: 10.4161/cam.22164. Epub 2012 Oct 17.

Abstract

Homeobox genes represent a family of highly conserved transcription factors originally discovered to regulate organ patterning during development. More recently, several homeobox genes were shown to affect processes in adult tissue, including angiogenesis and wound healing. Whereas a subset of members of the Hox-family of homeobox genes activate growth and migration to promote angiogenesis or wound healing, other Hox genes function to restore or maintain quiescent, differentiated tissue function. Pathological tissue remodeling is linked to differential expression of activating or stabilizing Hox genes and dysregulation of Hox expression can contribute to disease progression. Studies aimed at understanding the role and regulation of Hox genes have provided insight into how these potent morphoregulatory genes can be applied to enhance tissue engineering or limit cancer progression.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Survival
  • Chemokine CCL2 / genetics
  • Chemokine CCL2 / metabolism
  • Disease Progression
  • Endothelial Cells / metabolism
  • Gene Expression Regulation, Neoplastic*
  • Genes, Homeobox*
  • Homeodomain Proteins / genetics
  • Homeodomain Proteins / metabolism
  • Humans
  • Neoplasm Metastasis
  • Neoplasms / genetics
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Neovascularization, Pathologic / genetics*
  • Neovascularization, Pathologic / metabolism
  • Neovascularization, Pathologic / pathology
  • Transcriptional Activation
  • Wound Healing*

Substances

  • CCL2 protein, human
  • Chemokine CCL2
  • HOXA5 protein, human
  • Homeodomain Proteins