Laminin α5 guides tissue patterning and organogenesis

Cell Adh Migr. Jan-Feb 2013;7(1):90-100. doi: 10.4161/cam.22236. Epub 2012 Oct 17.

Abstract

Laminins (LM) are extracellular matrix molecules that contribute to and are required for the formation of basement membranes. They participate in the modulation of epithelial/mesenchymal interactions and are implicated in organogenesis and maintenance of organ homeostasis. Among the LM molecules, the LM α5 chain (LMα5) is one of the most widely distributed LM in the developing and mature organism. Its presence in some basement membranes during embryogenesis is absolutely required for maintenance of basement membrane integrity and thus for proper organogenesis. LMα5 also regulates the expression of genes important for major biological processes, in part by repressing or activating signaling pathways, depending upon the physiological context.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basement Membrane / cytology
  • Basement Membrane / metabolism
  • Binding Sites
  • Body Patterning*
  • Cell Differentiation
  • Cell Movement
  • Extracellular Matrix / genetics
  • Extracellular Matrix / metabolism
  • Gene Expression Regulation, Developmental*
  • Laminin / genetics
  • Laminin / metabolism*
  • Mice
  • Organogenesis*
  • Protein Binding
  • Stem Cells / cytology
  • Stem Cells / metabolism
  • Syndecan-4 / genetics
  • Syndecan-4 / metabolism
  • Wnt Signaling Pathway

Substances

  • Laminin
  • Sdc4 protein, mouse
  • Syndecan-4
  • laminin alpha5