Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2013 Feb;6(1):31-6.
doi: 10.1007/s12265-012-9416-1. Epub 2012 Oct 18.

Modeling long-QT Syndromes With iPS Cells


Modeling long-QT Syndromes With iPS Cells

Daniel Sinnecker et al. J Cardiovasc Transl Res. .


The generation of induced pluripotent stem cells (iPSC) from human somatic cells bears the possibility to generate patient-specific stem cell lines which can serve as a theoretically unlimited source of somatic cells carrying the genotype of the patients. Different types of the long-QT syndrome have been studied by analyzing the phenotype of cardiomyocytes generated from patient-specific iPSC lines. Major aspects of the pathophysiology of long-QT syndrome, like prolonged action potentials, arrhythmia, and the effects of pro- and antiarrhythmic drugs could be recapitulated in these cells. In the future, patient-specific iPSC-derived cardiomyocytes might be used to screen for new drugs, to avoid unwanted drug side effects, and to deepen our understanding on the pathophysiology of long-QT syndromes.

Similar articles

See all similar articles

Cited by 12 articles

See all "Cited by" articles


    1. Nature. 2009 Sep 17;461(7262):402-6 - PubMed
    1. JAMA. 2002 May 1;287(17):2215-20 - PubMed
    1. Proc Natl Acad Sci U S A. 2009 Jun 16;106(24):9826-30 - PubMed
    1. EMBO Mol Med. 2012 Mar;4(3):180-91 - PubMed
    1. Nature. 2009 Jan 15;457(7227):277-80 - PubMed

Publication types

MeSH terms

LinkOut - more resources