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, 21 (6), 1465-9

An α-Carbonic Anhydrase From the Thermophilic Bacterium Sulphurihydrogenibium Azorense Is the Fastest Enzyme Known for the CO2 Hydration Reaction

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An α-Carbonic Anhydrase From the Thermophilic Bacterium Sulphurihydrogenibium Azorense Is the Fastest Enzyme Known for the CO2 Hydration Reaction

Viviana De Luca et al. Bioorg Med Chem.

Abstract

We report the biochemical characterization of a new carbonic anhydrase (CA, EC 4.2.1.1), named SazCA, identified by translated genome inspection in Sulfurihydrogenibium azorense, a thermophilic bacterium from terrestrial hot springs of the Azores. SazCA is an α-CA showing kinetic parameters that make it the fastest enzyme of the CA family described so far. The biochemical properties, thermostability and inhibition of SazCA were compared with those of the thermophilic and mesophilic counterparts, demonstrating the special features of this unique enzyme.

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