Association between biomarkers of obesity and risk of high-grade prostatic intraepithelial neoplasia and prostate cancer--evidence of effect modification by prostate size

Cancer Lett. 2013 Jan 28;328(2):345-52. doi: 10.1016/j.canlet.2012.10.010. Epub 2012 Oct 16.


Prostate enlargement is common with aging and obesity. We investigated the association between obesity and prostate cancer controlling for differential detection related to prostate enlargement. In an analysis of 500 men, we found body mass index, waist-hip ratio, and blood leptin levels were significantly associated with high-grade PC, but only among men without prostate enlargement. Leptin was also significantly associated with high-grade prostatic intraepithelial neoplasia (HGPIN) in the absence of prostate enlargement. Our results suggest obesity advances prostate carcinogenesis, and that detection biases at prostate biopsy may explain past inconsistencies in the association between obesity and PC.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Aged
  • Biomarkers
  • Biopsy
  • Body Weights and Measures
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Grading
  • Obesity / blood*
  • Obesity / complications
  • Organ Size
  • Prostate / pathology*
  • Prostatic Intraepithelial Neoplasia / blood*
  • Prostatic Intraepithelial Neoplasia / complications
  • Prostatic Intraepithelial Neoplasia / pathology*
  • Prostatic Neoplasms / blood*
  • Prostatic Neoplasms / complications
  • Prostatic Neoplasms / pathology*
  • Risk


  • Biomarkers