Introduction: The mast cell is an immunocyte, but its functions in the brain remain unclear.
Materials and methods: In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.
Conclusion: We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.