Decrease of cerebral mast cell degranulation after systemic administration of lipopolysaccharide

Inflamm Res. 2012 Dec;61(12):1295-7. doi: 10.1007/s00011-012-0565-0. Epub 2012 Oct 19.


Introduction: The mast cell is an immunocyte, but its functions in the brain remain unclear.

Materials and methods: In a rat model of weak inflammation, we analyzed the effect of a gram-negative bacterial lipopolysaccharide injection (100 μg/kg) on thalamic mast cell (MC) population.

Conclusion: We demonstrate a significant decrease of their degranulation, which suggests the implication of MC in preventing sepsis on the brain.

MeSH terms

  • Animals
  • Cell Degranulation / drug effects*
  • Cell Degranulation / physiology
  • Disease Models, Animal
  • Encephalitis / chemically induced
  • Encephalitis / immunology*
  • Lipopolysaccharides / pharmacology*
  • Male
  • Mast Cells / drug effects*
  • Mast Cells / physiology
  • Rats
  • Rats, Wistar
  • Thalamus / drug effects*
  • Thalamus / physiology


  • Lipopolysaccharides