Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2012 Nov;13(11):798-810.
doi: 10.1038/nrn3353.

The BCM theory of synapse modification at 30: interaction of theory with experiment

Leon N Cooper  1 , Mark F Bear
Affiliations
Review

The BCM theory of synapse modification at 30: interaction of theory with experiment

Leon N Cooper et al. Nat Rev Neurosci. 2012 Nov.

Abstract

Thirty years have passed since the publication of Elie Bienenstock, Leon Cooper and Paul Munro's 'Theory for the development of neuron selectivity: orientation specificity and binocular interaction in visual cortex', known as the BCM theory of synaptic plasticity. This theory has guided experimentalists to discover some fundamental properties of synaptic plasticity and has provided a mathematical structure that bridges molecular mechanisms and systems-level consequences of learning and memory storage.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. J Neurophysiol. 2001 Jul;86(1):321-5 - PubMed
    1. Science. 1988 Oct 7;242(4875):81-4 - PubMed
    1. Nature. 2011 Nov 23;480(7375):63-8 - PubMed
    1. Proc Natl Acad Sci U S A. 2011 Nov 29;108(48):19103-4 - PubMed
    1. Trends Neurosci. 2007 Mar;30(3):111-8 - PubMed

Publication types

LinkOut - more resources