Double hydrogen-bonding pH-sensitive hydrogels retaining high-strengths over a wide pH range

Macromol Rapid Commun. 2013 Jan 11;34(1):63-8. doi: 10.1002/marc.201200548. Epub 2012 Oct 18.


Traditional pH-sensitive hydrogels inevitably suffer strength deterioration while the responsive weak acid or base groups are in the ionized state. In this study, we report on a facile approach to fabricate a novel pH-sensitive high-strength hydrogel from copolymerization of two hydrogen-bonding motif-containing monomers, 3-acrylamidophenylboronic acid and 2-vinyl-4,6-diamino-1,3,5-triazine with a crosslinker N,N-methylenebisacrylamide through hydrophilic optimization of the comonomer oligo(ethylene glycol) methacrylate. The double hydrogen bonding hydrogel exhibits both high tensile and compressive strengths over a broad pH range due to the unique ability to maintain at least one type of hydrogen-bonding crosslink over the whole course of pH change.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acrylamides / chemistry
  • Boronic Acids / chemical synthesis
  • Boronic Acids / chemistry
  • Hydrogels / chemistry*
  • Hydrogen Bonding
  • Hydrogen-Ion Concentration
  • Methacrylates / chemistry
  • Triazines / chemistry
  • Vinyl Compounds / chemistry


  • 2-vinyl-4,6-diamino-1,3,5-triazine
  • 3-acrylamidophenylboronic acid
  • Acrylamides
  • Boronic Acids
  • Hydrogels
  • Methacrylates
  • Triazines
  • Vinyl Compounds
  • N,N'-methylenebisacrylamide