A peptide photoaffinity probe specific for the active conformation of the Abl tyrosine kinase

Chembiochem. 2012 Nov 26;13(17):2510-2. doi: 10.1002/cbic.201200560. Epub 2012 Oct 18.


The design of sensors to monitor the activity state of specific protein kinases is challenging due to the complexity of eukaryotic kinomes. Here we describe a peptide-based photaffinity probe that specifically labels the active conformation of the Abl tyrosine kinase.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • HEK293 Cells
  • Humans
  • Models, Molecular
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Peptides / metabolism*
  • Photoaffinity Labels / chemistry*
  • Photoaffinity Labels / metabolism*
  • Protein Conformation
  • Proto-Oncogene Proteins c-abl / chemistry*
  • Proto-Oncogene Proteins c-abl / metabolism*
  • Substrate Specificity


  • Peptides
  • Photoaffinity Labels
  • Proto-Oncogene Proteins c-abl