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Meta-Analysis
, 7 (10), e47791

Active Smoking and Risk of Metabolic Syndrome: A Meta-Analysis of Prospective Studies

Affiliations
Meta-Analysis

Active Smoking and Risk of Metabolic Syndrome: A Meta-Analysis of Prospective Studies

Kan Sun et al. PLoS One.

Abstract

Background: Epidemiological evidence suggests that smoking has been associated with emergence of metabolic syndrome. However, data on this issue are inconsistent and controversial. We therefore conducted a meta-analysis to examine the association between smoking and metabolic syndrome.

Methodology and principal findings: We searched the Medline, Embase and the Cochrane Library database up to March 2012 to identify prospective cohort studies related to smoking and metabolic syndrome. Reference lists of retrieved articles were also reviewed. Summary effect estimates were derived using a random-effects model and stratified by gender, smoking dose, follow-up duration and geographical area. Primary analysis of 13 studies involving 56,691 participants and 8,688 cases detected a significant positive association between active smoking and risk of metabolic syndrome (pooled relative risk [RR] 1.26, 95% CI: 1.10-1.44). Estimates of effects were substantially consistent in the stratified analyses. In the dose-response analysis, risk of metabolic syndrome was stronger for active male smokers (pooled RR 1.34, 95% CI: 1.20-1.50) than it was for former male smokers (pooled RR 1.19, 95% CI: 1.00-1.42), and greater for heavy smokers (pooled RR 1.42, 95% CI: 1.27-1.59) compared with light smokers (pooled RR 1.10, 95% CI: 0.90-1.35). No evidence of statistical publication bias was found (Egger' s test P=0.227, Begg' s test P=0.113).

Conclusions: Active smoking is associated with development of metabolic syndrome. Smoking cessation appears to reduce the risk of metabolic syndrome.

Conflict of interest statement

Competing Interests: The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Flow diagram of study selection process.
Figure 2
Figure 2. Relative risks of metabolic syndrome for active smokers compared with nonsmokers.
Figure 3
Figure 3. Relative risks of metabolic syndrome for former smokers compared with nonsmokers in male.

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References

    1. World Health Organization (2011) Tobacco Free Initiative: Why Is Tobacco a Public Health Priority. World Health Organization website. Available at: http://www.who.int/tobacco/health_priority/en/. Accessed 2012 Sep 23.
    1. International Diabetes Foundation (2006) The IDF consensus worldwide definition of the metabolic syndrome. Brussels, Belgium: IDF Communications.
    1. Balhara YP (2012) Tobacco and metabolic syndrome. Indian J Endocrinol Metab 16: 81–87. - PMC - PubMed
    1. Cena H, Fonte ML, Turconi G (2011) Relationship between smoking and metabolic syndrome. Nutrition Reviews 69: 745–753. - PubMed
    1. Onat A, Ozhan H, Esen AM, Albayrak S, Karabulut A, et al. (2007) Prospective epidemiologic evidence of a “protective” effect of smoking on metabolic syndrome and diabetes among Turkish women–without associated overall health benefit. Atherosclerosis 193: 380–388. - PubMed

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