Cefovecin (Convenia) for the treatment of septic peritonitis in a female lion (Panthera leo)

J Zoo Wildl Med. 2012 Sep;43(3):678-81. doi: 10.1638/2012-0038R.1.


An 8-yr-old intact female African lion (Panthera leo) presented with a 3-day history of lethargy, anorexia, and vomiting. Hematologic and biochemical abnormalities included a leukocytosis, 41,700/microl (4,700-15,300) with a neutrophilia (37,530/microl; 2,000-9,200) and a left shift (1,250/microl bands; 0-300), and mild hypokalemia of 2.1 mEq/L (2.8-4.8). Abdominal radiographs revealed evidence of intestinal ileus, peritonitis, and the presence of effusion. An exploratory laparotomy was performed, and septic peritonitis due to a pyometra was diagnosed. The lion was treated with an ovariohysterectomy, abdominal lavage, fluid therapy, and a subcutaneous injection of cefovecin. The lion recovered, and clinical signs associated with septic peritonitis resolved within 36 hr. It was returned to conspecifics 3 wk later. Three months postoperatively, the lion showed no residual signs of septic peritonitis.

Publication types

  • Case Reports

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use*
  • Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
  • Cephalosporins / therapeutic use*
  • Female
  • Hysterectomy / veterinary
  • Lions*
  • Meloxicam
  • Pain / drug therapy
  • Pain / veterinary
  • Peritonitis / drug therapy
  • Peritonitis / veterinary*
  • Pyometra / surgery
  • Pyometra / veterinary
  • Sepsis / drug therapy
  • Sepsis / veterinary*
  • Thiazines / therapeutic use
  • Thiazoles / therapeutic use


  • Anti-Bacterial Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Cephalosporins
  • Thiazines
  • Thiazoles
  • cefovecin
  • Meloxicam