Gastrointestinal type 1 hypersensitivity to azathioprine

Klin Wochenschr. 1990 Jan 4;68(1):50-2. doi: 10.1007/BF01648893.


We report the case of a 49-year-old patient with progressive sensomotor polyneuropathy who developed nausea, vomiting, and diarrhea after 2 1/2 months of azathioprine therapy. Administration of the drug was interrupted. These symptoms recurred immediately after rechallenge with azathioprine. A duodenal biopsy demonstrated a massive local eosinophilia without peripheral blood eosinophilia. Cutane testing with azathioprine showed a positive type 1 reaction. We diagnosed a hypersensitive reaction type 1 in the duodenal mucosa on the basis of the histological features, the history, and the cutane reaction.

Publication types

  • Case Reports

MeSH terms

  • Azathioprine / adverse effects*
  • Drug Hypersensitivity / pathology*
  • Edema / pathology
  • Eosinophilia / pathology
  • Gastroenteritis / chemically induced*
  • Gastroenteritis / pathology
  • Humans
  • Intestinal Mucosa / pathology
  • Male
  • Middle Aged
  • Motor Neurons / drug effects*
  • Polyneuropathies / drug therapy*
  • Sensation / drug effects*


  • Azathioprine