Photodynamic and photothermal effects of semiconducting and metallic-enriched single-walled carbon nanotubes

J Am Chem Soc. 2012 Oct 31;134(43):17862-5. doi: 10.1021/ja3079972. Epub 2012 Oct 19.


Semiconducting and metallic single-walled carbon nanotubes (s-SWNTs and m-SWNTs) were enriched by agarose gel chromatography and their photothermal and photodynamic effects were compared in H(2)O. Under near-infrared laser irradiation, s-SWNTs generated reactive oxygen species (ROS) more than m-SWNTs, whereas m-SWNTs produced heat more efficiently than s-SWNTs. More importantly, cancer cell killing by PDE of s-SWNTs has been disclosed for the first time.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Dose-Response Relationship, Drug
  • Drug Screening Assays, Antitumor
  • Humans
  • Nanotubes, Carbon / chemistry*
  • Photosensitizing Agents / chemistry
  • Photosensitizing Agents / pharmacology*
  • Reactive Oxygen Species / metabolism
  • Semiconductors
  • Structure-Activity Relationship
  • Temperature*


  • Antineoplastic Agents
  • Nanotubes, Carbon
  • Photosensitizing Agents
  • Reactive Oxygen Species