A prion-mediated mechanism for memory proposed in Drosophila

Neuron. 2012 Oct 18;76(2):260-2. doi: 10.1016/j.neuron.2012.10.001. Epub 2012 Oct 17.

Abstract

Memories are remarkably persistent, but rely on transient signaling. The prion-like properties of CPEB suggested a solution to this problem. The paper by Krüttner et al. (2012) in this issue of Neuron demonstrates that the prion-like domain of Drosophila CPEB functions independently of its RNA-binding domain for memory.

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