Epidemiology of spondyloarthritis

Rheum Dis Clin North Am. 2012 Aug;38(3):441-76. doi: 10.1016/j.rdc.2012.09.003.


Spondyloarthritis (SpA) represents a group of interrelated diseases with common clinical features and a close association with HLA-B27. Reports of incidence and prevalence of diseases vary depending on methodological differences between studies, the case definition used to classify disease, and the prevalence of HLA-B27 in the population studied. Newly proposed criteria for axial SpA and peripheral SpA present a new approach to facilitate classification of the SpA into 2 main subtypes and the criteria allow earlier detection of patents with inflammatory back pain. These criteria were developed for use in a (specialized) clinical setting and not for large epidemiologic studies.

Publication types

  • Review

MeSH terms

  • Arthritis, Psoriatic / epidemiology*
  • Arthritis, Reactive / epidemiology*
  • Back Pain / epidemiology
  • Biomarkers / blood
  • Comorbidity
  • HLA-B7 Antigen / blood
  • Humans
  • Inflammatory Bowel Diseases / epidemiology*
  • Spondylarthritis / classification*
  • Spondylarthritis / diagnosis
  • Spondylarthritis / epidemiology*
  • Spondylarthritis / immunology
  • Spondylitis, Ankylosing / epidemiology*


  • Biomarkers
  • HLA-B7 Antigen