Mature oocyte cryopreservation: a guideline

Fertil Steril. 2013 Jan;99(1):37-43. doi: 10.1016/j.fertnstert.2012.09.028. Epub 2012 Oct 22.


There is good evidence that fertilization and pregnancy rates are similar to IVF/ICSI with fresh oocytes when vitrified/warmed oocytes are used as part of IVF/ICSI for young women. Although data are limited, no increase in chromosomal abnormalities, birth defects, and developmental deficits has been reported in the offspring born from cryopreserved oocytes when compared to pregnancies from conventional IVF/ICSI and the general population. Evidence indicates that oocyte vitrification and warming should no longer be considered experimental. This document replaces the document last published in 2008 titled, "Ovarian Tissue and Oocyte Cryopreservation," Fertil Steril 2008;90:S241-6.

Publication types

  • Guideline

MeSH terms

  • Cellular Senescence / physiology
  • Cryopreservation / methods*
  • Female
  • Fertilization in Vitro*
  • Humans
  • Oocytes / physiology*
  • Pregnancy
  • Pregnancy Outcome
  • Pregnancy Rate
  • Sperm Injections, Intracytoplasmic*
  • United States