The irritable bowel syndrome-celiac disease connection

Gastrointest Endosc Clin N Am. 2012 Oct;22(4):623-37. doi: 10.1016/j.giec.2012.07.009. Epub 2012 Aug 20.


Irritable bowel syndrome (IBS) is a prevalent functional gastrointestinal disorder that has a significant impact on quality of life and health care resources. Celiac disease (CD), a gluten-sensitive enteropathy, can be mistaken for IBS. This article discusses the connection between IBS and CD and the new concept of nonceliac gluten sensitivity (NCGS). NCGS may occur in the presence of a normal or near-normal small bowel biopsy. Some patients with IBS without CD may derive symptomatic benefit from a gluten-free diet. Future research could facilitate a significant impact on the quality of life in this potential subgroup of patients.

Publication types

  • Review

MeSH terms

  • Celiac Disease / complications
  • Celiac Disease / diagnosis*
  • Celiac Disease / diet therapy
  • Celiac Disease / physiopathology
  • Cost of Illness
  • Diagnosis, Differential
  • Diet, Gluten-Free
  • Humans
  • Irritable Bowel Syndrome / complications
  • Irritable Bowel Syndrome / diagnosis*
  • Irritable Bowel Syndrome / diet therapy
  • Irritable Bowel Syndrome / physiopathology
  • Wheat Hypersensitivity / diagnosis*