Preliminary results of the first human uterus transplantation from a multiorgan donor

Fertil Steril. 2013 Feb;99(2):470-6. doi: 10.1016/j.fertnstert.2012.09.035. Epub 2012 Oct 18.


Objective: To describe the first-year results of the first human uterus transplantation case from a multiorgan donor.

Design: Case study.

Setting: University hospital.

Patient(s): A 21-year-old woman with complete müllerian agenesis who had been previously operated on for vaginal reconstruction.

Intervention(s): Uterus transplantation procedure consisting of orthotopic replacement and fixation of the retrieved uterus, revascularization, end to site anastomoses of bilateral hypogastric arteries and veins to bilateral external iliac arteries and veins was performed.

Main outcome measure(s): Resumption of menstrual cycles.

Result(s): The patient had menarche 20 days after transplant surgery. She has had 12 menstrual cycles since the operation.

Conclusion(s): We have described the longest-lived transplanted human uterus to date with acquirement of menstrual cycles.

Publication types

  • Case Reports

MeSH terms

  • Anastomosis, Surgical / methods
  • Female
  • Humans
  • Menstrual Cycle / physiology
  • Pilot Projects
  • Tissue and Organ Procurement
  • Treatment Outcome
  • Uterus / abnormalities*
  • Uterus / physiology
  • Uterus / surgery
  • Uterus / transplantation*
  • Vagina / abnormalities*
  • Vagina / surgery*
  • Young Adult