Corifollitropin alfa followed by rFSH in a GnRH antagonist protocol for poor ovarian responder patients: an observational pilot study

Fertil Steril. 2013 Feb;99(2):422-6. doi: 10.1016/j.fertnstert.2012.09.043. Epub 2012 Oct 16.


Objective: To identify whether women with poor ovarian response may benefit from treatment with corifollitropin alfa in a GnRH antagonist protocol.

Design: Retrospective pilot study.

Setting: University-based tertiary care center.

Patient(s): Poor ovarian responders fulfilling the Bologna criteria developed by European Society for Human Reproduction and Embryology Consensus Group.

Intervention(s): Corifollitropin alfa (150 μg) followed by 300 IU rFSH in a GnRH antagonist protocol.

Main outcome measure(s): Endocrinologic profile and ongoing pregnancy rates.

Result(s): Among 43 women treated with corifollitropin alfa, mean E(2) levels showed an increasing pattern during the follicular phase, reaching 825 ng/L on the day of hCG administration, whereas FSH values showed a marked increase during the first 5 days, reaching a mean value of 35 IU/L and remaining above 20 IU/L during the late follicular phase. Cycle cancellation rate was 32.6% and embryo transfer rate 53.3%. Five patients (11.7%) had a positive hCG test and three (7%) had an ongoing pregnancy. Ongoing pregnancy rates were 11.1% per oocyte retrieval and 13% per embryo transfer. Ongoing pregnancy rates per patient did not significantly differ compared with a cohort of patients treated during 2011 with the standard protocol for poor responders in our center (short agonist-hMG) (7% vs. 6.3%).

Conclusion(s): Treatment of poor ovarian responders, as described by the Bologna criteria, with corifollitropin alfa in a GnRH antagonist protocol results in low pregnancy rates, similarly to conventional stimulation with a short agonist protocol.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Drug Therapy, Combination
  • Female
  • Follicle Stimulating Hormone / administration & dosage*
  • Follicle Stimulating Hormone, Human / administration & dosage*
  • Gonadotropin-Releasing Hormone / antagonists & inhibitors*
  • Hormone Antagonists / administration & dosage
  • Humans
  • Infertility, Female / diagnosis*
  • Infertility, Female / drug therapy*
  • Ovulation Induction / methods*
  • Pilot Projects
  • Pregnancy
  • Pregnancy Outcome*
  • Recombinant Proteins
  • Retrospective Studies
  • Treatment Outcome


  • Follicle Stimulating Hormone, Human
  • Hormone Antagonists
  • Recombinant Proteins
  • follicle stimulating hormone, human, with HCG C-terminal peptide
  • Gonadotropin-Releasing Hormone
  • Follicle Stimulating Hormone