Insights Into Tuberculosis From the Zebrafish Model

Trends Mol Med. 2012 Dec;18(12):689-90. doi: 10.1016/j.molmed.2012.10.002. Epub 2012 Oct 17.

Abstract

Mycobacterium tuberculosis (MTB) continues to plague humanity because of significant gaps in our understanding of MTB infection, including the nature of a protective versus pathological host response, why antimicrobial cure is so difficult, and the ineffectiveness of vaccination. The development of a zebrafish model, utilizing infection with the natural fish pathogen Mycobacterium marinum (Mm), has yielded important insights into tuberculosis with immediate clinical applications.

MeSH terms

  • Animals
  • Disease Models, Animal*
  • Granuloma / pathology
  • Mycobacterium marinum*
  • Tuberculosis / physiopathology*
  • Zebrafish*