Precision editing of large animal genomes

Adv Genet. 2012:80:37-97. doi: 10.1016/B978-0-12-404742-6.00002-8.


Transgenic animals are an important source of protein and nutrition for most humans and will play key roles in satisfying the increasing demand for food in an ever-increasing world population. The past decade has experienced a revolution in the development of methods that permit the introduction of specific alterations to complex genomes. This precision will enhance genome-based improvement of farm animals for food production. Precision genetics also will enhance the development of therapeutic biomaterials and models of human disease as resources for the development of advanced patient therapies.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Domestic / genetics
  • Animals, Genetically Modified
  • Disease Models, Animal*
  • Food Supply
  • Genetic Engineering* / legislation & jurisprudence
  • Genetic Engineering* / methods
  • Genome
  • Humans
  • Meat*