IFN-inducible GTPases in host cell defense

Cell Host Microbe. 2012 Oct 18;12(4):432-44. doi: 10.1016/j.chom.2012.09.007.


From plants to humans, the ability to control infection at the level of an individual cell-a process termed cell-autonomous immunity-equates firmly with survival of the species. Recent work has begun to unravel this programmed cell-intrinsic response and the central roles played by IFN-inducible GTPases in defending the mammalian cell's interior against a diverse group of invading pathogens. These immune GTPases regulate vesicular traffic and protein complex assembly to stimulate oxidative, autophagic, membranolytic, and inflammasome-related antimicrobial activities within the cytosol, as well as on pathogen-containing vacuoles. Moreover, human genome-wide association studies and disease-related transcriptional profiling have linked mutations in the Immunity-Related GTPase M (IRGM) locus and altered expression of guanylate binding proteins (GBPs) with tuberculosis susceptibility and Crohn's colitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Crohn Disease / immunology
  • Cytoplasmic Vesicles / metabolism
  • GTP Phosphohydrolases / immunology*
  • GTP Phosphohydrolases / metabolism
  • Humans
  • Interferons / immunology*
  • Interferons / metabolism
  • Tuberculosis / immunology


  • Interferons
  • GTP Phosphohydrolases